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  <element name="MinimumExpectedPrepaymentOfDebt" id="tgtx_MinimumExpectedPrepaymentOfDebt" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <element name="PercentageOfPrepaymentCharge" id="tgtx_PercentageOfPrepaymentCharge" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="PercentageOfInterestOnPastDueOutstanding" id="tgtx_PercentageOfInterestOnPastDueOutstanding" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="DebtInstrumentFourthAdvanceAvailable" id="tgtx_DebtInstrumentFourthAdvanceAvailable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <element name="LesseeOperatingLeaseRemainingTermOfContract" id="tgtx_LesseeOperatingLeaseRemainingTermOfContract" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="NumberOfLeasesWithRenewalOption" id="tgtx_NumberOfLeasesWithRenewalOption" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <element name="ScheduleOfBalanceSheetClassificationOfOperatingLeaseTableTextBlock" id="tgtx_ScheduleOfBalanceSheetClassificationOfOperatingLeaseTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="ContractManufacturerMember" id="tgtx_ContractManufacturerMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="MinimumIndebtednessInvolvedByBorrowerInDefault" id="tgtx_MinimumIndebtednessInvolvedByBorrowerInDefault" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <element name="InterestExpenseRecognizedAsAdministrativeFees" id="tgtx_InterestExpenseRecognizedAsAdministrativeFees" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <element name="WarrantCoveragePercentage" id="tgtx_WarrantCoveragePercentage" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="DeferredTaxAssetDisallowedInterest" id="tgtx_DeferredTaxAssetDisallowedInterest" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <element name="AtMarket2017Member" id="tgtx_AtMarket2017Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="NonCashStockExpenseAssociatedWithInLicensingAgreements" id="tgtx_NonCashStockExpenseAssociatedWithInLicensingAgreements" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <element name="StockIssuedDuringPeriodValueInLicensingAgreements" id="tgtx_StockIssuedDuringPeriodValueInLicensingAgreements" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <element name="SharesIssuedInConnectionWithInLicensingAgreements" id="tgtx_SharesIssuedInConnectionWithInLicensingAgreements" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="SharesIssuedInConnectionWithInLicensingAgreement" id="tgtx_SharesIssuedInConnectionWithInLicensingAgreement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <element name="IssuanceOfCommonStockInAtMarketOfferingNetOfOfferingCosts" id="tgtx_IssuanceOfCommonStockInAtMarketOfferingNetOfOfferingCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <element name="IssuanceOfCommonStockInAtMarketOfferingNetOfOfferingCostsShares" id="tgtx_IssuanceOfCommonStockInAtMarketOfferingNetOfOfferingCostsShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="OfferingCosts" id="tgtx_OfferingCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <element name="OfferingCostsAtMarket" id="tgtx_OfferingCostsAtMarket" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <element name="WarrantExercisableTerm" id="tgtx_WarrantExercisableTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="AgreementCostsAggregate" id="tgtx_AgreementCostsAggregate" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <element name="AtMarket2020Member" id="tgtx_AtMarket2020Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="UnderwrittenPublicOfferingMember" id="tgtx_UnderwrittenPublicOfferingMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="NjLeaseMember" id="tgtx_NjLeaseMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="SharesIssuedInConnectionWithInLicensingAgreementsValue" id="tgtx_SharesIssuedInConnectionWithInLicensingAgreementsValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <element name="IcfrAuditorAttestationFlag" id="tgtx_IcfrAuditorAttestationFlag" type="xbrli:booleanItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="LfbLicenseAgreementMember" id="tgtx_LfbLicenseAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="StockAndWarrantsIssuedDuringPeriodSharesPreferredStockAndWarrants" id="tgtx_StockAndWarrantsIssuedDuringPeriodSharesPreferredStockAndWarrants" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="AtMarket2021Member" id="tgtx_AtMarket2021Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="LfbBiotechnologiesMember" id="tgtx_LfbBiotechnologiesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
</schema>
