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  <element name="CumulativeLiabilityOfNote" id="tgtx_CumulativeLiabilityOfNote" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <element name="PercentageOfCashProceedsFromOperationToRepayConvertibleDebt" id="tgtx_PercentageOfCashProceedsFromOperationToRepayConvertibleDebt" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="LeaseholdInterest" id="tgtx_LeaseholdInterest" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <element name="PrepaidResearchAndDevelopment" id="tgtx_PrepaidResearchAndDevelopment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <element name="NonCashCompensationResearchAndDevelopmentExpenses" id="tgtx_NonCashCompensationResearchAndDevelopmentExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <element name="ChangeInFairValueOfNotesPayable" id="tgtx_ChangeInFairValueOfNotesPayable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <element name="ProceedsFromMaturities" id="tgtx_ProceedsFromMaturities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <element name="PaymentsToAcquireHeldToMaturitySecuritiesShortTerm" id="tgtx_PaymentsToAcquireHeldToMaturitySecuritiesShortTerm" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <element name="LiquidityDisclosure1PolicyTextBlock" id="tgtx_LiquidityDisclosure1PolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="LicenseAgreementDisclosureTextBlock" id="tgtx_LicenseAgreementDisclosureTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="ManhattanAndAristonPharmaceuticalsMergerMember" id="tgtx_ManhattanAndAristonPharmaceuticalsMergerMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="LfbGroupMember" id="tgtx_LfbGroupMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="SharedServicesAgreementMember" id="tgtx_SharedServicesAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="StockOptionsMember" id="tgtx_StockOptionsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="LicenseAgreementAbstract" id="tgtx_LicenseAgreementAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="FairValueMeasurementTable" id="tgtx_FairValueMeasurementTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="FairValueMeasurementLineItems" id="tgtx_FairValueMeasurementLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="EquityIncentivePlansStockOptionActivityTable" id="tgtx_EquityIncentivePlansStockOptionActivityTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="EquityIncentivePlansStockOptionActivityLineItems" id="tgtx_EquityIncentivePlansStockOptionActivityLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="EquityIncentivePlansRestrictedStockActivityTable" id="tgtx_EquityIncentivePlansRestrictedStockActivityTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="EquityIncentivePlansRestrictedStockActivityLineItems" id="tgtx_EquityIncentivePlansRestrictedStockActivityLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="UpfrontFeeReceivedFromSubLicense" id="tgtx_UpfrontFeeReceivedFromSubLicense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <element name="Tg1101Member" id="tgtx_Tg1101Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="Tg1701Member" id="tgtx_Tg1701Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="Tg1801Member" id="tgtx_Tg1801Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="NumberOfPayments" id="tgtx_NumberOfPayments" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <element name="NumberOfObligations" id="tgtx_NumberOfObligations" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <element name="CommonStockCommissionRate" id="tgtx_CommonStockCommissionRate" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <element name="OfficeSpaceLeaseInitialCommitmentPeriod" id="tgtx_OfficeSpaceLeaseInitialCommitmentPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="AdditionalAmountReceivableOnAchievementOfPreSpecifiedMilestones" id="tgtx_AdditionalAmountReceivableOnAchievementOfPreSpecifiedMilestones" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <element name="NumberOfOncologyIndications" id="tgtx_NumberOfOncologyIndications" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <element name="NumberOfNonOncologyIndications" id="tgtx_NumberOfNonOncologyIndications" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <element name="TermAfterFirstCommercialSale" id="tgtx_TermAfterFirstCommercialSale" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="AmendedAndRestated2012IncentivePlanMember" id="tgtx_AmendedAndRestated2012IncentivePlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="MilestoneBasedRestrictedStockMember" id="tgtx_MilestoneBasedRestrictedStockMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="EndOfTermFee" id="tgtx_EndOfTermFee" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <element id="tgtx_LongTermDebtGross" name="LongTermDebtGross" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <element name="ClassOfWarrantOrRightFairValue" id="tgtx_ClassOfWarrantOrRightFairValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <element name="ScheduleOfLongTermDebtKeyAssumptionsTableTextBlock" id="tgtx_ScheduleOfLongTermDebtKeyAssumptionsTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="tgtx_ScheduleOfLongTermDebtTextBlock" name="ScheduleOfLongTermDebtTextBlock" nillable="true" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="tgtx_OperatingLeaseInitialCommitmentPeriod" name="OperatingLeaseInitialCommitmentPeriod" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element name="OfficeAgreementMember" id="tgtx_OfficeAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="PercentageOfOccupancy" id="tgtx_PercentageOfOccupancy" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="AverageAnnualRentalPayments" id="tgtx_AverageAnnualRentalPayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <element name="TermLoanMember" id="tgtx_TermLoanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="WithinFirstTwelveMonthsOfClosingDateMember" id="tgtx_WithinFirstTwelveMonthsOfClosingDateMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="AfterTwelveMonthsButOnOrBeforeTwentyFourMonthsMember" id="tgtx_AfterTwelveMonthsButOnOrBeforeTwentyFourMonthsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="AfterTwentyFourMonthsOfClosingDateMember" id="tgtx_AfterTwentyFourMonthsOfClosingDateMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="NumberOfAdvances" id="tgtx_NumberOfAdvances" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <element name="DebtInstrumentFirstAdvanceDrawn" id="tgtx_DebtInstrumentFirstAdvanceDrawn" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <element id="tgtx_AdditionalAdvancesForEachDraw" name="AdditionalAdvancesForEachDraw" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <element name="MinimumAmountRaisedFromUnrestrictedCashProceeds" id="tgtx_MinimumAmountRaisedFromUnrestrictedCashProceeds" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <element name="NumberOfBusinessDays" id="tgtx_NumberOfBusinessDays" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <element name="MinimumExpectedPrepaymentOfDebt" id="tgtx_MinimumExpectedPrepaymentOfDebt" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <element name="PercentageOfPrepaymentCharge" id="tgtx_PercentageOfPrepaymentCharge" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="PercentageOfInterestOnPastDueOutstanding" id="tgtx_PercentageOfInterestOnPastDueOutstanding" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="LesseeOperatingLeaseRemainingTermOfContract" id="tgtx_LesseeOperatingLeaseRemainingTermOfContract" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="NumberOfLeasesWithRenewalOption" id="tgtx_NumberOfLeasesWithRenewalOption" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <element name="ScheduleOfBalanceSheetClassificationOfOperatingLeaseTableTextBlock" id="tgtx_ScheduleOfBalanceSheetClassificationOfOperatingLeaseTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="MinimumIndebtednessInvolvedByBorrowerInDefault" id="tgtx_MinimumIndebtednessInvolvedByBorrowerInDefault" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <element name="WarrantCoveragePercentage" id="tgtx_WarrantCoveragePercentage" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="tgtx_OfferingCosts" name="OfferingCosts" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <element name="AtMarket2020Member" id="tgtx_AtMarket2020Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="NjLeaseMember" id="tgtx_NjLeaseMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="LicenseAndCollaborationAgreementsMilestonePaymentMade" id="tgtx_LicenseAndCollaborationAgreementsMilestonePaymentMade" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <element name="LicenseAndCollaborationAgreementExpensesIncurred" id="tgtx_LicenseAndCollaborationAgreementExpensesIncurred" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <element name="Tgr1202Member" id="tgtx_Tgr1202Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="TG1501Member" id="tgtx_TG1501Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="LfbLicenseAgreementMember" id="tgtx_LfbLicenseAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="Tgr1202UmbralisibMember" id="tgtx_Tgr1202UmbralisibMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element id="tgtx_RepaymentOfOfferingCosts" name="RepaymentOfOfferingCosts" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="tgtx_OperatingLeaseLiabilityIncrementalBorrowingRate" name="OperatingLeaseLiabilityIncrementalBorrowingRate" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <element id="tgtx_GrossToNetAdjustments" name="GrossToNetAdjustments" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="tgtx_SalesReturnsAndAllowances" name="SalesReturnsAndAllowances" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="tgtx_TradeDiscountsAndAllowances" name="TradeDiscountsAndAllowances" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="tgtx_GovernmentRebatesAndCoPaymentAssistance" name="GovernmentRebatesAndCoPaymentAssistance" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="tgtx_RevenueGross" name="RevenueGross" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="tgtx_GrossNetAccruals" name="GrossNetAccruals" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <element id="tgtx_NetProductRevenue" name="NetProductRevenue" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="tgtx_NonCashCompensationSellingGeneralAndAdministrativeExpenses" name="NonCashCompensationSellingGeneralAndAdministrativeExpenses" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="tgtx_UmbralisibLicenseAgreementMember" name="UmbralisibLicenseAgreementMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
</schema>
