<?xml version="1.0" encoding="us-ascii"?>
<!--iXBRL Document Created from Secfly-->
<!-- -->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xlink="http://www.w3.org/1999/xlink" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns:xbrli="http://www.xbrl.org/2003/instance">
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/Cover" xlink:href="tgtx-20190930.xsd#Cover" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/CondensedConsolidatedBalanceSheetsUnaudited" xlink:href="tgtx-20190930.xsd#CondensedConsolidatedBalanceSheetsUnaudited" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/CondensedConsolidatedBalanceSheetsParenthetical" xlink:href="tgtx-20190930.xsd#CondensedConsolidatedBalanceSheetsParenthetical" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/CondensedConsolidatedStatementsofOperationsUnaudited" xlink:href="tgtx-20190930.xsd#CondensedConsolidatedStatementsofOperationsUnaudited" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/CondensedConsolidatedStatementsofStockholdersDeficitEquityUnaudited" xlink:href="tgtx-20190930.xsd#CondensedConsolidatedStatementsofStockholdersDeficitEquityUnaudited" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/CondensedConsolidatedStatementsofStockholdersDeficitEquityParenthetical" xlink:href="tgtx-20190930.xsd#CondensedConsolidatedStatementsofStockholdersDeficitEquityParenthetical" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/CondensedConsolidatedStatementsofCashFlowsUnaudited" xlink:href="tgtx-20190930.xsd#CondensedConsolidatedStatementsofCashFlowsUnaudited" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/OrganizationandSummaryofSignificantAccountingPolicies" xlink:href="tgtx-20190930.xsd#OrganizationandSummaryofSignificantAccountingPolicies" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/CashandCashEquivalents" xlink:href="tgtx-20190930.xsd#CashandCashEquivalents" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/InvestmentSecurities" xlink:href="tgtx-20190930.xsd#InvestmentSecurities" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/FairValueMeasurements" xlink:href="tgtx-20190930.xsd#FairValueMeasurements" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/StockholdersEquity" xlink:href="tgtx-20190930.xsd#StockholdersEquity" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/OtherLiabilities" xlink:href="tgtx-20190930.xsd#OtherLiabilities" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/LongtermDebt" xlink:href="tgtx-20190930.xsd#LongtermDebt" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/Leases" xlink:href="tgtx-20190930.xsd#Leases" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/LicenseAgreements" xlink:href="tgtx-20190930.xsd#LicenseAgreements" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/RelatedPartyTransactions" xlink:href="tgtx-20190930.xsd#RelatedPartyTransactions" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/SubsequentEvents" xlink:href="tgtx-20190930.xsd#SubsequentEvents" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/OrganizationandSummaryofSignificantAccountingPoliciesPolicies" xlink:href="tgtx-20190930.xsd#OrganizationandSummaryofSignificantAccountingPoliciesPolicies" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/OrganizationandSummaryofSignificantAccountingPoliciesTables" xlink:href="tgtx-20190930.xsd#OrganizationandSummaryofSignificantAccountingPoliciesTables" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/CashandCashEquivalentsTables" xlink:href="tgtx-20190930.xsd#CashandCashEquivalentsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/InvestmentSecuritiesTables" xlink:href="tgtx-20190930.xsd#InvestmentSecuritiesTables" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/FairValueMeasurementsTables" xlink:href="tgtx-20190930.xsd#FairValueMeasurementsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/StockholdersEquityTables" xlink:href="tgtx-20190930.xsd#StockholdersEquityTables" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/OtherLiabilitiesTables" xlink:href="tgtx-20190930.xsd#OtherLiabilitiesTables" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/LongtermDebtTables" xlink:href="tgtx-20190930.xsd#LongtermDebtTables" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/LeasesTables" xlink:href="tgtx-20190930.xsd#LeasesTables" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/OrganizationandSummaryofSignificantAccountingPoliciesDetails" xlink:href="tgtx-20190930.xsd#OrganizationandSummaryofSignificantAccountingPoliciesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/OrganizationandSummaryofSignificantAccountingPoliciesDetailsNarrative" xlink:href="tgtx-20190930.xsd#OrganizationandSummaryofSignificantAccountingPoliciesDetailsNarrative" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/CashandCashEquivalentsDetails" xlink:href="tgtx-20190930.xsd#CashandCashEquivalentsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/InvestmentSecuritiesDetails" xlink:href="tgtx-20190930.xsd#InvestmentSecuritiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/FairValueMeasurementsDetails" xlink:href="tgtx-20190930.xsd#FairValueMeasurementsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/FairValueMeasurementsDetails1" xlink:href="tgtx-20190930.xsd#FairValueMeasurementsDetails1" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/FairValueMeasurementsDetailsNarrative" xlink:href="tgtx-20190930.xsd#FairValueMeasurementsDetailsNarrative" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/StockholdersEquityDetails" xlink:href="tgtx-20190930.xsd#StockholdersEquityDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/StockholdersEquityDetails1" xlink:href="tgtx-20190930.xsd#StockholdersEquityDetails1" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/StockholdersEquityDetails2" xlink:href="tgtx-20190930.xsd#StockholdersEquityDetails2" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/StockholdersEquityDetails3" xlink:href="tgtx-20190930.xsd#StockholdersEquityDetails3" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/StockholdersEquityDetails4" xlink:href="tgtx-20190930.xsd#StockholdersEquityDetails4" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/StockholdersEquityDetailsNarrative" xlink:href="tgtx-20190930.xsd#StockholdersEquityDetailsNarrative" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/OtherLiabilitiesDetails" xlink:href="tgtx-20190930.xsd#OtherLiabilitiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/OtherLiabilitiesDetailsNarrative" xlink:href="tgtx-20190930.xsd#OtherLiabilitiesDetailsNarrative" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/LongtermDebtDetails" xlink:href="tgtx-20190930.xsd#LongtermDebtDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/LongtermDebtDetails1" xlink:href="tgtx-20190930.xsd#LongtermDebtDetails1" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/LongtermDebtDetailsNarrative" xlink:href="tgtx-20190930.xsd#LongtermDebtDetailsNarrative" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/LeasesDetails" xlink:href="tgtx-20190930.xsd#LeasesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/LeasesDetails1" xlink:href="tgtx-20190930.xsd#LeasesDetails1" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/LeasesDetails2" xlink:href="tgtx-20190930.xsd#LeasesDetails2" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/LeasesDetailsNarrative" xlink:href="tgtx-20190930.xsd#LeasesDetailsNarrative" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/LicenseAgreementsDetailsNarrative" xlink:href="tgtx-20190930.xsd#LicenseAgreementsDetailsNarrative" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/RelatedPartyTransactionsDetailsNarrative" xlink:href="tgtx-20190930.xsd#RelatedPartyTransactionsDetailsNarrative" xlink:type="simple" />
  <link:roleRef roleURI="http://tgtherapeuticsinc.com/role/SubsequentEventsDetailsNarrative" xlink:href="tgtx-20190930.xsd#SubsequentEventsDetailsNarrative" xlink:type="simple" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/Cover" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/CondensedConsolidatedBalanceSheetsUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsCurrent" xlink:label="loc_us-gaapAssetsCurrent" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaapCashAndCashEquivalentsAtCarryingValue" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssetsCurrent" xlink:to="loc_us-gaapCashAndCashEquivalentsAtCarryingValue" order="1" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShortTermInvestments" xlink:label="loc_us-gaapShortTermInvestments" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssetsCurrent" xlink:to="loc_us-gaapShortTermInvestments" order="2" weight="1" />
    <link:loc xlink:type="locator" xlink:href="tgtx-20190930.xsd#tgtx_PrepaidResearchAndDevelopment" xlink:label="loc_tgtxPrepaidResearchAndDevelopment" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssetsCurrent" xlink:to="loc_tgtxPrepaidResearchAndDevelopment" order="3" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherAssetsCurrent" xlink:label="loc_us-gaapOtherAssetsCurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssetsCurrent" xlink:to="loc_us-gaapOtherAssetsCurrent" order="4" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Assets" xlink:label="loc_us-gaapAssets" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalentsNoncurrent" xlink:label="loc_us-gaapRestrictedCashAndCashEquivalentsNoncurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssets" xlink:to="loc_us-gaapRestrictedCashAndCashEquivalentsNoncurrent" order="2" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaapPropertyPlantAndEquipmentNet" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssets" xlink:to="loc_us-gaapPropertyPlantAndEquipmentNet" order="4" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeaseRightOfUseAsset" xlink:label="loc_us-gaapOperatingLeaseRightOfUseAsset" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssets" xlink:to="loc_us-gaapOperatingLeaseRightOfUseAsset" order="5" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaapGoodwill" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssets" xlink:to="loc_us-gaapGoodwill" order="6" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LiabilitiesCurrent" xlink:label="loc_us-gaapLiabilitiesCurrent" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent" xlink:label="loc_us-gaapAccountsPayableAndAccruedLiabilitiesCurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesCurrent" xlink:to="loc_us-gaapAccountsPayableAndAccruedLiabilitiesCurrent" order="1" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherLiabilitiesCurrent" xlink:label="loc_us-gaapOtherLiabilitiesCurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesCurrent" xlink:to="loc_us-gaapOtherLiabilitiesCurrent" order="2" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeaseLiabilityCurrent" xlink:label="loc_us-gaapOperatingLeaseLiabilityCurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesCurrent" xlink:to="loc_us-gaapOperatingLeaseLiabilityCurrent" order="3" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredCompensationLiabilityCurrent" xlink:label="loc_us-gaapDeferredCompensationLiabilityCurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesCurrent" xlink:to="loc_us-gaapDeferredCompensationLiabilityCurrent" order="4" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Liabilities" xlink:label="loc_us-gaapLiabilities" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredRentCreditNoncurrent" xlink:label="loc_us-gaapDeferredRentCreditNoncurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilities" xlink:to="loc_us-gaapDeferredRentCreditNoncurrent" order="2" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredRevenueNoncurrent" xlink:label="loc_us-gaapDeferredRevenueNoncurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilities" xlink:to="loc_us-gaapDeferredRevenueNoncurrent" order="3" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongTermDebtNoncurrent" xlink:label="loc_us-gaapLongTermDebtNoncurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilities" xlink:to="loc_us-gaapLongTermDebtNoncurrent" order="4" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent" xlink:label="loc_us-gaapOperatingLeaseLiabilityNoncurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilities" xlink:to="loc_us-gaapOperatingLeaseLiabilityNoncurrent" order="5" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrent" xlink:label="loc_us-gaapOtherLiabilitiesNoncurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilities" xlink:to="loc_us-gaapOtherLiabilitiesNoncurrent" order="6" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:label="loc_us-gaapStockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockValue" xlink:label="loc_us-gaapPreferredStockValue" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapStockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:to="loc_us-gaapPreferredStockValue" order="1" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockValue" xlink:label="loc_us-gaapCommonStockValue" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapStockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:to="loc_us-gaapCommonStockValue" order="2" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdditionalPaidInCapital" xlink:label="loc_us-gaapAdditionalPaidInCapital" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapStockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:to="loc_us-gaapAdditionalPaidInCapital" order="3" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TreasuryStockValue" xlink:label="loc_us-gaapTreasuryStockValue" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapStockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:to="loc_us-gaapTreasuryStockValue" order="4" weight="-1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="loc_us-gaapRetainedEarningsAccumulatedDeficit" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapStockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:to="loc_us-gaapRetainedEarningsAccumulatedDeficit" order="5" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="loc_us-gaapLiabilitiesAndStockholdersEquity" />
  </link:calculationLink>
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/CondensedConsolidatedBalanceSheetsParenthetical" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/CondensedConsolidatedStatementsofOperationsUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense" xlink:label="loc_us-gaapResearchAndDevelopmentExpense" />
    <link:loc xlink:type="locator" xlink:href="tgtx-20190930.xsd#tgtx_NonCashStockExpenseAssociatedWithInLicensingAgreements" xlink:label="loc_tgtxNonCashStockExpenseAssociatedWithInLicensingAgreements" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapResearchAndDevelopmentExpense" xlink:to="loc_tgtxNonCashStockExpenseAssociatedWithInLicensingAgreements" order="1" weight="1" />
    <link:loc xlink:type="locator" xlink:href="tgtx-20190930.xsd#tgtx_NonCashCompensationResearchAndDevelopment" xlink:label="loc_tgtxNonCashCompensationResearchAndDevelopment" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapResearchAndDevelopmentExpense" xlink:to="loc_tgtxNonCashCompensationResearchAndDevelopment" order="2" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherResearchAndDevelopmentExpense" xlink:label="loc_us-gaapOtherResearchAndDevelopmentExpense" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapResearchAndDevelopmentExpense" xlink:to="loc_us-gaapOtherResearchAndDevelopmentExpense" order="3" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GeneralAndAdministrativeExpense" xlink:label="loc_us-gaapGeneralAndAdministrativeExpense" />
    <link:loc xlink:type="locator" xlink:href="tgtx-20190930.xsd#tgtx_NonCashCompensationGeneralAndAdministrativeExpenses" xlink:label="loc_tgtxNonCashCompensationGeneralAndAdministrativeExpenses" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapGeneralAndAdministrativeExpense" xlink:to="loc_tgtxNonCashCompensationGeneralAndAdministrativeExpenses" order="1" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherGeneralAndAdministrativeExpense" xlink:label="loc_us-gaapOtherGeneralAndAdministrativeExpense" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapGeneralAndAdministrativeExpense" xlink:to="loc_us-gaapOtherGeneralAndAdministrativeExpense" order="2" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingExpenses" xlink:label="loc_us-gaapOperatingExpenses" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingIncomeLoss" xlink:label="loc_us-gaapOperatingIncomeLoss" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaapRevenues" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapOperatingIncomeLoss" xlink:to="loc_us-gaapRevenues" order="1" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NonoperatingIncomeExpense" xlink:label="loc_us-gaapNonoperatingIncomeExpense" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestExpense" xlink:label="loc_us-gaapInterestExpense" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNonoperatingIncomeExpense" xlink:to="loc_us-gaapInterestExpense" order="1" weight="-1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherIncome" xlink:label="loc_us-gaapOtherIncome" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNonoperatingIncomeExpense" xlink:to="loc_us-gaapOtherIncome" order="2" weight="1" />
  </link:calculationLink>
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/CondensedConsolidatedStatementsofStockholdersDeficitEquityUnaudited" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/CondensedConsolidatedStatementsofStockholdersDeficitEquityParenthetical" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/CondensedConsolidatedStatementsofCashFlowsUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:label="loc_us-gaapNetCashProvidedByUsedInOperatingActivitiesContinuingOperations" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProfitLoss" xlink:label="loc_us-gaapProfitLoss" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="loc_us-gaapProfitLoss" order="1" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_us-gaapShareBasedCompensation" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="loc_us-gaapShareBasedCompensation" order="2" weight="1" />
    <link:loc xlink:type="locator" xlink:href="tgtx-20190930.xsd#tgtx_NoncashLicensingExpense" xlink:label="loc_tgtxNoncashLicensingExpense" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="loc_tgtxNoncashLicensingExpense" order="3" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Depreciation" xlink:label="loc_us-gaapDepreciation" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="loc_us-gaapDepreciation" order="4" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentIncomeAmortizationOfPremium" xlink:label="loc_us-gaapInvestmentIncomeAmortizationOfPremium" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="loc_us-gaapInvestmentIncomeAmortizationOfPremium" order="5" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AmortizationOfFinancingCosts" xlink:label="loc_us-gaapAmortizationOfFinancingCosts" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="loc_us-gaapAmortizationOfFinancingCosts" order="6" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AmortizationOfLeaseIncentives" xlink:label="loc_us-gaapAmortizationOfLeaseIncentives" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="loc_us-gaapAmortizationOfLeaseIncentives" order="7" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability" xlink:label="loc_us-gaapRightOfUseAssetObtainedInExchangeForOperatingLeaseLiability" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="loc_us-gaapRightOfUseAssetObtainedInExchangeForOperatingLeaseLiability" order="8" weight="1" />
    <link:loc xlink:type="locator" xlink:href="tgtx-20190930.xsd#tgtx_ChangeInFairValueOfNotesPayable" xlink:label="loc_tgtxChangeInFairValueOfNotesPayable" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="loc_tgtxChangeInFairValueOfNotesPayable" order="9" weight="-1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidExpensesOther" xlink:label="loc_us-gaapIncreaseDecreaseInPrepaidExpensesOther" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="loc_us-gaapIncreaseDecreaseInPrepaidExpensesOther" order="10" weight="-1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedInterestReceivableNet" xlink:label="loc_us-gaapIncreaseDecreaseInAccruedInterestReceivableNet" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="loc_us-gaapIncreaseDecreaseInAccruedInterestReceivableNet" order="11" weight="-1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInOtherAccountsPayableAndAccruedLiabilities" xlink:label="loc_us-gaapIncreaseDecreaseInOtherAccountsPayableAndAccruedLiabilities" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="loc_us-gaapIncreaseDecreaseInOtherAccountsPayableAndAccruedLiabilities" order="12" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInOtherAccruedLiabilities" xlink:label="loc_us-gaapIncreaseDecreaseInOtherAccruedLiabilities" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="loc_us-gaapIncreaseDecreaseInOtherAccruedLiabilities" order="13" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInInterestPayableNet" xlink:label="loc_us-gaapIncreaseDecreaseInInterestPayableNet" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="loc_us-gaapIncreaseDecreaseInInterestPayableNet" order="14" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInOtherCurrentLiabilities" xlink:label="loc_us-gaapIncreaseDecreaseInOtherCurrentLiabilities" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="loc_us-gaapIncreaseDecreaseInOtherCurrentLiabilities" order="15" weight="1" />
    <link:loc xlink:type="locator" xlink:href="tgtx-20190930.xsd#tgtx_IncreaseDecreaseInDeferredRent" xlink:label="loc_tgtxIncreaseDecreaseInDeferredRent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="loc_tgtxIncreaseDecreaseInDeferredRent" order="16" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInDeferredRevenue" xlink:label="loc_us-gaapIncreaseDecreaseInDeferredRevenue" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="loc_us-gaapIncreaseDecreaseInDeferredRevenue" order="17" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations" xlink:label="loc_us-gaapNetCashProvidedByUsedInInvestingActivitiesContinuingOperations" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment" xlink:label="loc_us-gaapPaymentsToAcquirePropertyPlantAndEquipment" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInInvestingActivitiesContinuingOperations" xlink:to="loc_us-gaapPaymentsToAcquirePropertyPlantAndEquipment" order="1" weight="-1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsForProceedsFromInvestments" xlink:label="loc_us-gaapPaymentsForProceedsFromInvestments" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInInvestingActivitiesContinuingOperations" xlink:to="loc_us-gaapPaymentsForProceedsFromInvestments" order="2" weight="-1" />
    <link:loc xlink:type="locator" xlink:href="tgtx-20190930.xsd#tgtx_ProceedsFromMaturities" xlink:label="loc_tgtxProceedsFromMaturities" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInInvestingActivitiesContinuingOperations" xlink:to="loc_tgtxProceedsFromMaturities" order="3" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations" xlink:label="loc_us-gaapNetCashProvidedByUsedInFinancingActivitiesContinuingOperations" />
    <link:loc xlink:type="locator" xlink:href="tgtx-20190930.xsd#tgtx_NetProceedsFromSharesNewIssuesOverallotments" xlink:label="loc_tgtxNetProceedsFromSharesNewIssuesOverallotments" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInFinancingActivitiesContinuingOperations" xlink:to="loc_tgtxNetProceedsFromSharesNewIssuesOverallotments" order="1" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromOtherDebt" xlink:label="loc_us-gaapProceedsFromOtherDebt" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInFinancingActivitiesContinuingOperations" xlink:to="loc_us-gaapProceedsFromOtherDebt" order="2" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentOfFinancingAndStockIssuanceCosts" xlink:label="loc_us-gaapPaymentOfFinancingAndStockIssuanceCosts" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInFinancingActivitiesContinuingOperations" xlink:to="loc_us-gaapPaymentOfFinancingAndStockIssuanceCosts" order="3" weight="-1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease" xlink:label="loc_us-gaapCashAndCashEquivalentsPeriodIncreaseDecrease" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:label="loc_us-gaapCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaapCashAndCashEquivalentsAtCarryingValue" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:to="loc_us-gaapCashAndCashEquivalentsAtCarryingValue" order="1" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestrictedCash" xlink:label="loc_us-gaapRestrictedCash" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:to="loc_us-gaapRestrictedCash" order="2" weight="1" />
  </link:calculationLink>
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/OrganizationandSummaryofSignificantAccountingPolicies" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/CashandCashEquivalents" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/InvestmentSecurities" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/FairValueMeasurements" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/StockholdersEquity" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/OtherLiabilities" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/LongtermDebt" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/Leases" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/LicenseAgreements" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/RelatedPartyTransactions" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/SubsequentEvents" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/OrganizationandSummaryofSignificantAccountingPoliciesPolicies" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/OrganizationandSummaryofSignificantAccountingPoliciesTables" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/CashandCashEquivalentsTables" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/InvestmentSecuritiesTables" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/FairValueMeasurementsTables" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/StockholdersEquityTables" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/OtherLiabilitiesTables" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/LongtermDebtTables" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/LeasesTables" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/OrganizationandSummaryofSignificantAccountingPoliciesDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/OrganizationandSummaryofSignificantAccountingPoliciesDetailsNarrative" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/CashandCashEquivalentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaapCashAndCashEquivalentsAtCarryingValue" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Cash" xlink:label="loc_us-gaapCash" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapCashAndCashEquivalentsAtCarryingValue" xlink:to="loc_us-gaapCash" order="1" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MoneyMarketFundsAtCarryingValue" xlink:label="loc_us-gaapMoneyMarketFundsAtCarryingValue" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapCashAndCashEquivalentsAtCarryingValue" xlink:to="loc_us-gaapMoneyMarketFundsAtCarryingValue" order="2" weight="1" />
  </link:calculationLink>
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/InvestmentSecuritiesDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/FairValueMeasurementsDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/FairValueMeasurementsDetails1" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/FairValueMeasurementsDetailsNarrative" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/StockholdersEquityDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/StockholdersEquityDetails1" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/StockholdersEquityDetails2" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/StockholdersEquityDetails3" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/StockholdersEquityDetails4" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/StockholdersEquityDetailsNarrative" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/OtherLiabilitiesDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/OtherLiabilitiesDetailsNarrative" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/LongtermDebtDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/LongtermDebtDetails1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:href="tgtx-20190930.xsd#tgtx_LongTermDebtGross" xlink:label="loc_tgtxLongTermDebtGross" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherLongTermDebt" xlink:label="loc_us-gaapOtherLongTermDebt" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_tgtxLongTermDebtGross" xlink:to="loc_us-gaapOtherLongTermDebt" order="1" weight="1" />
    <link:loc xlink:type="locator" xlink:href="tgtx-20190930.xsd#tgtx_EndOfTermFee" xlink:label="loc_tgtxEndOfTermFee" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_tgtxLongTermDebtGross" xlink:to="loc_tgtxEndOfTermFee" order="2" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongTermDebt" xlink:label="loc_us-gaapLongTermDebt" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_UnamortizedDebtIssuanceExpense" xlink:label="loc_us-gaapUnamortizedDebtIssuanceExpense" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLongTermDebt" xlink:to="loc_us-gaapUnamortizedDebtIssuanceExpense" order="2" weight="-1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongTermDebtNoncurrent" xlink:label="loc_us-gaapLongTermDebtNoncurrent" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongTermDebtCurrent" xlink:label="loc_us-gaapLongTermDebtCurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLongTermDebtNoncurrent" xlink:to="loc_us-gaapLongTermDebtCurrent" order="2" weight="1" />
  </link:calculationLink>
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/LongtermDebtDetailsNarrative" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/LeasesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LeaseCost" xlink:label="loc_us-gaapLeaseCost" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeaseCost" xlink:label="loc_us-gaapOperatingLeaseCost" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLeaseCost" xlink:to="loc_us-gaapOperatingLeaseCost" order="1" weight="1" />
  </link:calculationLink>
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/LeasesDetails1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeaseLiability" xlink:label="loc_us-gaapOperatingLeaseLiability" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeaseLiabilityCurrent" xlink:label="loc_us-gaapOperatingLeaseLiabilityCurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapOperatingLeaseLiability" xlink:to="loc_us-gaapOperatingLeaseLiabilityCurrent" order="1" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent" xlink:label="loc_us-gaapOperatingLeaseLiabilityNoncurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapOperatingLeaseLiability" xlink:to="loc_us-gaapOperatingLeaseLiabilityNoncurrent" order="2" weight="1" />
  </link:calculationLink>
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/LeasesDetails2" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue" xlink:label="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDue" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextRollingTwelveMonths" xlink:label="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDueNextRollingTwelveMonths" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDue" xlink:to="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDueNextRollingTwelveMonths" order="1" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueInRollingYearTwo" xlink:label="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDueInRollingYearTwo" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDue" xlink:to="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDueInRollingYearTwo" order="2" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueInRollingYearThree" xlink:label="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDueInRollingYearThree" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDue" xlink:to="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDueInRollingYearThree" order="3" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueInRollingYearFour" xlink:label="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDueInRollingYearFour" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDue" xlink:to="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDueInRollingYearFour" order="4" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueInRollingYearFive" xlink:label="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDueInRollingYearFive" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDue" xlink:to="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDueInRollingYearFive" order="5" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterRollingYearFive" xlink:label="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDueAfterRollingYearFive" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDue" xlink:to="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDueAfterRollingYearFive" order="6" weight="1" />
    <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeaseLiability" xlink:label="loc_us-gaapOperatingLeaseLiability" />
    <link:loc xlink:type="locator" xlink:href="tgtx-20190930.xsd#tgtx_OperatingLeaseLiabilityImputedInterest" xlink:label="loc_tgtxOperatingLeaseLiabilityImputedInterest" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapOperatingLeaseLiability" xlink:to="loc_tgtxOperatingLeaseLiabilityImputedInterest" order="2" weight="1" />
  </link:calculationLink>
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/LeasesDetailsNarrative" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/LicenseAgreementsDetailsNarrative" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/RelatedPartyTransactionsDetailsNarrative" xlink:type="extended" />
  <link:calculationLink xlink:role="http://tgtherapeuticsinc.com/role/SubsequentEventsDetailsNarrative" xlink:type="extended" />
</link:linkbase>
