Short-term Investments [Member] Schedule of Fair Value of Separate Accounts by Major Category of Investment [Axis] US Government Agencies Debt Securities [Member] Major Types of Debt and Equity Securities [Axis] Other Long-term Investments [Member] Convertible Notes Payable [Member] Short-term Debt, Type [Axis] Fair Value, Inputs, Level 1 [Member] Fair Value, Hierarchy [Axis] Fair Value, Inputs, Level 2 [Member] Fair Value, Inputs, Level 3 [Member] Unvested Restricted Stock [Member] Award Type [Axis] Warrant [Member] Financial Instrument [Axis] Convertible Notes [Member] Cash and Cash Equivalents [Axis] Ariston [Member] Business Acquisition [Axis] TG One One Zero One [Member] Legal Entity [Axis] Lfb Group [Member] Placement Agency Agreement [Axis] Opus [Member] Common Stock [Member] Equity Components [Axis] Contingently Issuable Share [Member] Additional Paid-in Capital [Member] Treasury Stock [Member] Accumulated Deficit [Member] Shared Services Agreement [Member] Agreement Type [Axis] LFB License Agreement [] [Member] Antidilutive Securities [Axis] Share Issuable Upon Note Conversion [Member] 2015 ATM Plan Name [Axis] 2012 Incentive Plan Office Agreement [Member] Fortress [Member] JBET Agreement [Member] Document And Entity Information [Abstract] Document Type Amendment Flag Document Period End Date Document Fiscal Year Focus Document Fiscal Period Focus Entity Registrant Name Entity Central Index Key Current Fiscal Year End Date Entity Filer Category Trading Symbol Entity Common Stock, Shares Outstanding Statement of Financial Position [Abstract] Assets Current assets: Cash and cash equivalents Short-term investment securities Interest receivable Prepaid research and development Other current assets Total current assets Restricted cash Long-term investment securities Leasehold interest Equipment, net Goodwill Other assets Total assets Liabilities and stockholders’ equity Current liabilities: Accounts payable and accrued expenses Accrued compensation Current portion of deferred revenue Notes payable Total current liabilities Deferred rent Deferred revenue, net of current portion Total liabilities Commitments and contingencies Stockholders’ equity: Preferred stock, $0.001 par value per share (10,000,000 shares authorized, none issued and outstanding as of September 30, 2016 and December 31, 2015) Common stock, $0.001 par value per share (150,000,000 shares authorized, 54,765,890 and 54,095,110 shares issued, 54,724,581 and 54,053,801 shares outstanding at September 30, 2016 and December 31, 2015, respectively) Contingently issuable shares Additional paid-in capital Treasury stock, at cost, 41,309 shares at September 30, 2016 and December 31, 2015 Accumulated deficit Total stockholders’ equity Total liabilities and stockholders’ equity Preferred stock, par value (in dollars per share) Preferred stock, shares authorized Preferred stock, shares issued Preferred stock, shares outstanding Common stock, par value (in dollars per share) Common stock, shares authorized Common stock, shares issued Common stock, shares outstanding Treasury stock, shares Income Statement [Abstract] License revenue Costs and expenses: Research and development: Noncash compensation Other research and development Total research and development General and administrative: Noncash compensation Other general and administrative Total general and administrative Total costs and expenses Operating loss Other (income) expense: Interest income Other income Interest expense Change in fair value of notes payable Total other income Net loss Basic and diluted net loss per common share Weighted average shares used in computing basic and diluted net loss per common share Statement [Table] Statement [Line Items] Compensation [Axis] Balance Balance (in shares) Issuance of common stock in connection with exercise of warrants Issuance of common stock in connection with exercise of warrants (in shares) Issuance of common stock in connection with conversion of notes payable Issuance of common stock in connection with conversion of notes payable (in shares) Issuance of restricted stock Issuance of restricted stock (in shares) Forfeiture of restricted stock Forfeiture of restricted stock (in shares) Issuance of common stock in At the Market offering (net of offering costs of $122,497) Issuance of common stock in At the Market offering (net of offering costs of $122,497) (in shares) Compensation in respect of restricted stock granted to employees, directors and consultants Net loss Balance Balance (in shares) Statement of Cash Flows [Abstract] CASH FLOWS FROM OPERATING ACTIVITIES: Adjustments to reconcile net loss to net cash used in operating activities: Gain on sale of long-term securities Noncash stock compensation expense Depreciation Amortization of premium on investment securities Change in fair value of notes payable and accrued interest Changes in assets and liabilities: Increase in restricted cash Increase in prepaid research and development and other current assets Increase in leasehold interest Decrease (increase) in accrued interest receivable Increase in other assets Increase in accounts payable and accrued expenses Increase in deferred rent Decrease in deferred revenue Net cash used in operating activities CASH FLOWS FROM INVESTING ACTIVITIES: Purchases of equipment Investment in held-to-maturity securities Proceeds from maturity of short-term securities Proceeds from sale of long-term securities Net cash provided by (used in) investing activities CASH FLOWS FROM FINANCING ACTIVITIES: Proceeds from the exercise of warrants Proceeds from sale of common stock, net Financing costs Net cash provided by financing activities NET (DECREASE) INCREASE IN CASH AND CASH EQUIVALENTS CASH AND CASH EQUIVALENTS AT BEGINNING OF PERIOD CASH AND CASH EQUIVALENTS AT END OF PERIOD NONCASH TRANSACTIONS Accrued financing costs Reclassification of deferred financing costs to additional paid-in capital Conversion of convertible notes payable to common stock Accounting Policies [Abstract] ORGANIZATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES Cash and Cash Equivalents [Abstract] CASH AND CASH EQUIVALENTS Investments, Debt and Equity Securities [Abstract] INVESTMENT SECURITIES Fair Value Disclosures [Abstract] FAIR VALUE MEASUREMENTS Stockholders' Equity Note [Abstract] STOCKHOLDERS' EQUITY Debt Disclosure [Abstract] NOTES PAYABLE License Agreement [Abstract] LICENSE AGREEMENTS Related Party Transactions [Abstract] RELATED PARTY TRANSACTIONS Business Description Liquidity Disclosure Recently Issued Accounting Standards Use of Estimates Cash and Cash Equivalents Cash and Cash Equivalents, Restricted Cash and Cash Equivalents Investment Securities Credit Risk Revenue Recognition Research and Development Costs Income Taxes Share-based Compensation, Option and Incentive Plans Earnings Per Share Impairment Of Tangible and Intangible Asset Including Goodwill Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share Schedule of Cash and Cash Equivalents Held-to-maturity Securities Fair Value, Liabilities Measured on Recurring and Nonrecurring Basis Change In Level Three Fair Value During Period Schedule of Nonvested Restricted Stock Units Activity Schedule Of Warrants Activity Schedule Of Share Based Compensation Expense Schedule of Debt Significant Accounting Policies [Table] Significant Accounting Policies [Line Items] Employee Stock Option [Member] Antidilutive Securities Excluded From Computation Of Earnings Per Share, Amount Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Period Anticipated Sufficient To Fund Operating Cash Flow Cash, Cash Equivalents, and Short-term Investments, Total Restricted Cash and Investments Prepaid Manufacturing Money market funds Checking and bank deposits Total Schedule of Held-to-maturity Securities [Table] Schedule of Held-to-maturity Securities [Line Items] Debt Instrument [Axis] Investment Type [Axis] Amortized cost, as adjusted Gross unrealized holding gains Gross unrealized holding losses Estimated fair value Fair Value, by Balance Sheet Grouping [Table] Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] 5% Notes Totals Fair value at December 31, 2015 Interest accrued on face value of 5% Notes Conversion of 5% notes Change in fair value of Level 3 liabilities Fair value at September 30, 2016 Equity Incentive Plans Restricted Stock Activity [Table] Equity Incentive Plans Restricted Stock Activity [Line Items] Class of Stock [Axis] Number of Shares, Outstanding at Beginning Balance Number of Shares, Granted Number of Shares, Vested Number of Shares, Forfeited Number of Shares, Outstanding at Ending Balance Weighted Average Grant Date Fair Value, Outstanding at Beginning Balance Weighted Average Grant Date Fair Value, Granted Weighted Average Grant Date Fair Value, Vested Weighted Average Grant Date Fair Value, Forfeited Weighted Average Grant Date Fair Value, Outstanding at Ending Balance Equity Incentive Plans Warrant Activity [Table] Equity Incentive Plans Warrant Activity [Line Items] Scenario [Axis] Warrants, Outstanding at Beginning Balance Warrants, Issued Warrants, Exercised Warrants, Expired Warrants, Outstanding at Ending Balance Weighted - average exercise price, Outstanding at Beginning Balance (in dollars per share) Weighted - average exercise price, Issued (in dollars per share) Weighted - average exercise price, Exercised (in dollars per share) Weighted - average exercise price, Expired (in dollars per share) Weighted - average exercise price, Outstanding at Ending Balance (in dollars per share) Aggregate Intrinsic Value, Outstanding at Beginning Balance (in dollars) Aggregate Intrinsic Value, Outstanding at Ending Balance (in dollars) Stock Based Compensation [Table] Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Stock-based compensation expense associated with restricted stock Stock-based compensation expense associated with option grants Allocated Share-based Compensation Expense Shares sold under plan Gross proceeds from sale off common stock Net proceeds from sale off common stock Selling price per share Employee Service Share-based Compensation, Nonvested Awards, Total Compensation Cost Not yet Recognized, Period for Recognition Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Total Options Outstanding Common Stock, Shares Authorized Share-based Compensation, Total Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant Common stock available for sale Notes Payable [Table] Notes Payable [Line Items] Notes payable, Current portion, net Notes payable, Non-current portion, net Total Percentage Of Cash Proceeds From Operation To Repay Interest On Convertible Debt Debt Instrument, Convertible, Conversion Price Long-term Debt, Gross Debt Instrument, Interest Rate During Period Debt Instrument, Maturity Date License Agreement [Table] License Agreement [Line Items] Income Statement Location [Axis] Indefinite-lived Intangible Assets [Axis] Range [Axis] Related Party [Axis] Upfront Fee Deferred Revenue Additional Amount Receivable On Achievement Of Pre Specified Milestones Income taxes Proceeds from Fees Received Schedule of Related Party Transactions, by Related Party [Table] Related Party Transaction [Line Items] Subsequent Event Type [Axis] Sale of Stock [Axis] Title of Individual [Axis] Issuance Period [Axis] Desk Agreement [Member] Research Development Expenses [Axis] Global Collaboration Agreement [Member] Accounts Payable Costs and Expenses, Related Party Prepaid Research And Development Average Annual Rental Payments Security Deposit Percentage of Occupancy Accounts Payable, Related Parties, Current Lessee Leasing Arrangements, Operating Leases, Term of Contract Area of Land Operating Lease, Initial Commitment Period Prepaid Rent Upfront Fee Received From Sub License Sublicense Fee paid Rent expense Deferred rent Build out costs Common stock issued Warrant to purchase common stock Common stock purchase price Additional shares available to purchase Reflects potential milestone payments to be received upon achievement of pre-specified milestone. The yearly payments due under the lease entered into in connection with the possession of the office space. Reflects the description of business of the entity. The change in the fair value of non current notes payable recognized during the period. The change in fair value of notes payable during the period. The shares issuable for merger of companies Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. Fair value disclosures related to financial assets (as defined) and financial liabilities (as defined) contained in the entity's balance sheet. Disclosures contained in this table include the changes in level 3 instruments. Amount of interest recognized during the period, arising from liabilities measured at fair value on a recurring basis using unobservable inputs (level 3). Disclosure related to policy for impairment of tangible and intangible asset including goodwill. represents incentives plan of 2012 Change during the period in carrying value for deferred rent due within one year or operating cycle. License Agreement [Abstract] The entire disclosure for research, development, and License Agreement activities, including contracts and arrangements to be performed for others and with federal government. Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. Represents the net proceeds from issuance of common stock over-allotments during the period. The aggregate compensation expense related to the grants of stock options and restricted stock that is attributable to general and administrative expenses during the reporting period. The aggregate compensation expense related to the grants of stock options and restricted stock that is attributable to research and development expenses during the reporting period. represents restricted shares outstanding issued to non-employees Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. The duration of initial lease commitment. Amount of cash outflow (inflow) through acquisition (sale) of short-term held-to-maturity securities. Occupancy percentage of the office space. Represents Placement Agency Agreement Represents Placement Agency Agreement. Represents the amount of prepaid manufacturing. Sum of the amounts paid in advance for capitalized costs that will be expensed with Research and development. The cash inflow associated with the maturities of held-to-maturity securities. Tabular disclosure of Share based compensation expense during the period. Tabular disclosure for warrants activity. Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. Schedule reflecting the organisation and summary of significant accounting policies. Represents the number of shares of stock issued during the period due to the exercise of warrants. Represents the value of stock issued during the period due to the exercise of warrants. Represents amount received for sub license. Reflects the aggregate intrinsic value of warrants outstanding. Reflects the number of warrants exercised during the period. Reflects the weighted average exercise price of warrants Exercised. Reflects the number of warrants expired during the period. Reflects the weighted average exercise price of warrants Expired. Reflects the number of warrants issued during the period. Reflects the weighted average exercise price of warrants issued. Reflects the weighted average exercise price of warrants outstanding. Reflects level of percentage of net product cash flow received from the exploitation or commercialization of certain product candidates to repay certain convertible debt. Assets, Current Assets [Default Label] Liabilities, Current Liabilities Treasury Stock, Value Stockholders' Equity, Including Portion Attributable to Noncontrolling Interest Liabilities and Equity Research and Development Expense Non Cash Compensation General and Administrative Expenses General and Administrative Expense Operating Expenses Operating Income (Loss) Interest Income, Other Other Income Change In Fair Value Of Non Current Note Payable Nonoperating Income (Expense) Shares, Outstanding Change In Fair Value Of Notes Payable Increase (Decrease) in Restricted Cash Increase (Decrease) in Other Current Assets Increase (Decrease) in Prepaid Rent Increase (Decrease) in Accrued Interest Receivable, Net Increase (Decrease) in Other Noncurrent Assets Net Cash Provided by (Used in) Operating Activities, Continuing Operations Payments to Acquire Property, Plant, and Equipment Payments To Acquire Held To Maturity Securities Short Term Net Cash Provided by (Used in) Investing Activities, Continuing Operations Payments of Financing Costs Net Cash Provided by (Used in) Financing Activities, Continuing Operations Cash and Cash Equivalents, Period Increase (Decrease) Fair Value, Measurement with Unobservable Inputs Reconciliations, Recurring Basis, Liability Value Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeited in Period Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value Class of Warrant or Right, Outstanding Warrant Or Right Exercised Warrant Or Right Expired Warrant Or Right Outstanding Weighted Average Exercise Price Warrant Or Right Aggregate Intrinsic Value Notes Payable Deferred Rent Credit Fair Value, Measurement Changes In Level 3 Instruments [Line Items] Fair Value, Measurement Changes In Level 3 Instruments [Table] Incentive Plan [Member] Non Employee Restricted Stock [Member] Placement Agency Agreement [Domain]