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<import namespace="http://xbrl.sec.gov/stpr/2011-01-31" schemaLocation="http://xbrl.sec.gov/stpr/2011/stpr-2011-01-31.xsd"/>
<import namespace="http://www.xbrl.org/2009/role/negated" schemaLocation="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd"/>
<import namespace="http://www.xbrl.org/2009/role/net" schemaLocation="http://www.xbrl.org/lrr/role/net-2009-12-16.xsd"/>
<import namespace="http://www.xbrl.org/2009/arcrole/fact-explanatoryFact" schemaLocation="http://www.xbrl.org/lrr/arcrole/factExplanatory-2009-12-16.xsd"/>
<import namespace="http://xbrl.sec.gov/dei/2012-01-31" schemaLocation="http://xbrl.sec.gov/dei/2012/dei-2012-01-31.xsd"/>
<import namespace="http://www.xbrl.org/dtr/type/numeric" schemaLocation="http://www.xbrl.org/dtr/type/numeric-2009-12-16.xsd"/>
<import namespace="http://www.xbrl.org/dtr/type/non-numeric" schemaLocation="http://www.xbrl.org/dtr/type/nonNumeric-2009-12-16.xsd"/>
<import namespace="http://fasb.org/us-types/2012-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2012/elts/us-types-2012-01-31.xsd"/>
<element name="DocumentAndEntityInformationAbstract" id="tgtxd_DocumentAndEntityInformationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PrepaidResearchAndDevelopment" id="tgtxd_PrepaidResearchAndDevelopment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="InProcessResearchAndDevelopment" id="tgtxd_InProcessResearchAndDevelopment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ContingentlyIssuableShares" id="tgtxd_ContingentlyIssuableShares" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NonCashStockExpense" id="tgtxd_NonCashStockExpense" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NonCashCompensationResearchAndDevelopmentExpenses" id="tgtxd_NonCashCompensationResearchAndDevelopmentExpenses" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="OtherResearchAndDevelopment" id="tgtxd_OtherResearchAndDevelopment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NonCashCompensationGeneralAndAdministrativeExpenses" id="tgtxd_NonCashCompensationGeneralAndAdministrativeExpenses" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ChangeInFairValueOfNonCurrentNotePayable" id="tgtxd_ChangeInFairValueOfNonCurrentNotePayable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="TotalTGTherapeuticsIncAndSubsidiariesEquityMember" id="tgtxd_TotalTGTherapeuticsIncAndSubsidiariesEquityMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="StockIssuedDuringPeriodValueNewIssuesNetofExpenses" id="tgtxd_StockIssuedDuringPeriodValueNewIssuesNetofExpenses" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="SharesIssuedToNonControllingInterestInConnectionWithLicensingAgreement" id="tgtxd_SharesIssuedToNonControllingInterestInConnectionWithLicensingAgreement" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PreferredStockIssued" id="tgtxd_PreferredStockIssued" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ChangeInFairValueOfNotesPayable" id="tgtxd_ChangeInFairValueOfNotesPayable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ConversionOfNotesPayableToPreferredStock" id="tgtxd_ConversionOfNotesPayableToPreferredStock" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="AccruedFinancingCosts" id="tgtxd_AccruedFinancingCosts" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="LicenseAgreementAbstract" id="tgtxd_LicenseAgreementAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="LicenseAgreementDisclosureTextBlock" id="tgtxd_LicenseAgreementDisclosureTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="LiquidityAndCapitalDisclosurePolicyTextBlock" id="tgtxd_LiquidityAndCapitalDisclosurePolicyTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ReverseStockSplitPolicyPolicyTextBlock" id="tgtxd_ReverseStockSplitPolicyPolicyTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ChangeInLevelThreeFairValueDuringPeriodTableTextBlock" id="tgtxd_ChangeInLevelThreeFairValueDuringPeriodTableTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ScheduleOfPurchasePriceComputationTableTextBlock" id="tgtxd_ScheduleOfPurchasePriceComputationTableTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="IssuancePeriodAxis" id="tgtxd_IssuancePeriodAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem"/>
<element name="IssuancePeriodDomain" id="tgtxd_IssuancePeriodDomain" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="TwoThousandAndElevenIssuanceMember" id="tgtxd_TwoThousandAndElevenIssuanceMember" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="TwoThousandAndTwelveIssuanceMember" id="tgtxd_TwoThousandAndTwelveIssuanceMember" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="FairValuePerShareIssued" id="tgtxd_FairValuePerShareIssued" type="num:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ClassOfWarrantOrRightsExercisablePeriod" id="tgtxd_ClassOfWarrantOrRightsExercisablePeriod" type="xbrli:durationItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PreferredStockToCommonStockConversionBasisPerShare" id="tgtxd_PreferredStockToCommonStockConversionBasisPerShare" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CashEquivalentsMaturityPeriod" id="tgtxd_CashEquivalentsMaturityPeriod" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NonCashCompensationsExpenses" id="tgtxd_NonCashCompensationsExpenses" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityInterestAccruedIncludedInEarnings" id="tgtxd_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityInterestAccruedIncludedInEarnings" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="TypeOfTransactionAxis" id="tgtxd_TypeOfTransactionAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem"/>
<element name="TypeOfTransactionDomain" id="tgtxd_TypeOfTransactionDomain" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ManhattanAndAristonPharmaceuticalsMergerMember" id="tgtxd_ManhattanAndAristonPharmaceuticalsMergerMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="DebtInstrumentMaturityPeriod" id="tgtxd_DebtInstrumentMaturityPeriod" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PercentageOfCashProceedsFromOperationToRepayConvertibleDebt" id="tgtxd_PercentageOfCashProceedsFromOperationToRepayConvertibleDebt" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="BusinessAcquisitionSharesOutstandingAcquiredEntity" id="tgtxd_BusinessAcquisitionSharesOutstandingAcquiredEntity" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="BusinessAcquisitionFairValeOfSharesIssued" id="tgtxd_BusinessAcquisitionFairValeOfSharesIssued" type="num:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="BusinessAcquisitionFairValueofCommonStockOutstanding" id="tgtxd_BusinessAcquisitionFairValueofCommonStockOutstanding" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="FairValueOfRestrictedSharesAcquired" id="tgtxd_FairValueOfRestrictedSharesAcquired" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="IconAndSwissPharmaMember" id="tgtxd_IconAndSwissPharmaMember" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ExcludingIconAndSwissPharmaMember" id="tgtxd_ExcludingIconAndSwissPharmaMember" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="BusinessAcquisitionPurchasePriceAllocationInProcessResearchAndDevelopmentAquired" id="tgtxd_BusinessAcquisitionPurchasePriceAllocationInProcessResearchAndDevelopmentAquired" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="BusinessAcquisitionPurchasePriceAllocationAccountsPayableAndAccruedLiablities" id="tgtxd_BusinessAcquisitionPurchasePriceAllocationAccountsPayableAndAccruedLiablities" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="BusinessAcquisitionPurchasePriceAllocationAssetsAcquiredLiabilitiesAssumedNetBeforeAllocationOfGoodwill" id="tgtxd_BusinessAcquisitionPurchasePriceAllocationAssetsAcquiredLiabilitiesAssumedNetBeforeAllocationOfGoodwill" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="BusinessAcquisitionProformaEarningsPerShareBasicAndDiluted" id="tgtxd_BusinessAcquisitionProformaEarningsPerShareBasicAndDiluted" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="BusinessAcquisitionSharesRepurchasedPercentage" id="tgtxd_BusinessAcquisitionSharesRepurchasedPercentage" type="num:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="BusinessAcquisitionSharesNotAcquired" id="tgtxd_BusinessAcquisitionSharesNotAcquired" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="BusinessAcquisitionAcquiredEntityShareholdersCumulativePercentageofCommonStockOwnershipAfterTransaction" id="tgtxd_BusinessAcquisitionAcquiredEntityShareholdersCumulativePercentageofCommonStockOwnershipAfterTransaction" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" abstract="false" nillable="true"/>

<element name="ConversionOfPreferredStockToRestrictedCommonStock" id="tgtxd_ConversionOfPreferredStockToRestrictedCommonStock" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ConvertedPreferredStock" id="tgtxd_ConvertedPreferredStock" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ConversionOfPreferredStockToRestrictedCommonStockWeightedAverageGrantDateFairValue" id="tgtxd_ConversionOfPreferredStockToRestrictedCommonStockWeightedAverageGrantDateFairValue" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValue" id="tgtxd_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ClassOfWarrantOrRightIssued" id="tgtxd_ClassOfWarrantOrRightIssued" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ClassOfWarrantOrRightExcersiced" id="tgtxd_ClassOfWarrantOrRightExcersiced" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ClassOfWarrantOrRightExpired" id="tgtxd_ClassOfWarrantOrRightExpired" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ClassOfWarrantOrRightOutstandingWeightedAverageExercisePrice" id="tgtxd_ClassOfWarrantOrRightOutstandingWeightedAverageExercisePrice" type="num:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ClassOfWarrantOrRightIssuedWeightedAverageExercisePrice" id="tgtxd_ClassOfWarrantOrRightIssuedWeightedAverageExercisePrice" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ClassOfWarrantOrRightExercisedWeightedAverageExercisePrice" id="tgtxd_ClassOfWarrantOrRightExercisedWeightedAverageExercisePrice" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ClassOfWarrantOrRightExpiredWeightedAverageExercisePrice" id="tgtxd_ClassOfWarrantOrRightExpiredWeightedAverageExercisePrice" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ClassOfWarrantOrRightAggregateIntrinsicValue" id="tgtxd_ClassOfWarrantOrRightAggregateIntrinsicValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="InvestorCategoryAxis" id="tgtxd_InvestorCategoryAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem"/>
<element name="InvestorCategoryDomain" id="tgtxd_InvestorCategoryDomain" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PlacementAgentMember" id="tgtxd_PlacementAgentMember" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="TwoThousandTwelveIncentivePlanMember" id="tgtxd_TwoThousandTwelveIncentivePlanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CorporateMileStoneAxis" id="tgtxd_CorporateMileStoneAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem"/>
<element name="CorporateMileStoneDomain" id="tgtxd_CorporateMileStoneDomain" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CorporateMileStoneMember" id="tgtxd_CorporateMileStoneMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NonEmployeeStockOptionsAxis" id="tgtxd_NonEmployeeStockOptionsAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem"/>
<element name="NonEmployeeStockOptionsDomain" id="tgtxd_NonEmployeeStockOptionsDomain" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NonEmployeeStockOptionsMember" id="tgtxd_NonEmployeeStockOptionsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="AgentCashCommissionPercentageOnProceedsFromSharesIssuance" id="tgtxd_AgentCashCommissionPercentageOnProceedsFromSharesIssuance" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostYetToBeRecognized" id="tgtxd_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostYetToBeRecognized" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ShareBasedCompensationNonEmployeeStockOptionsOutstanding" id="tgtxd_ShareBasedCompensationNonEmployeeStockOptionsOutstanding" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="UnallocatedShareBasedCompensation" id="tgtxd_UnallocatedShareBasedCompensation" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NotesPayableNonInterestBearingCurrent" id="tgtxd_NotesPayableNonInterestBearingCurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NotesPayableNonInterestBearingNoncurrent" id="tgtxd_NotesPayableNonInterestBearingNoncurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NotesPayableNonInterestBearingCurrentAndNoncurrent" id="tgtxd_NotesPayableNonInterestBearingCurrentAndNoncurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NameOfEntityAxis" id="tgtxd_NameOfEntityAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem"/>
<element name="NameOfEntityDomain" id="tgtxd_NameOfEntityDomain" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="IconClinicalResearchMember" id="tgtxd_IconClinicalResearchMember" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="AmendmentAxis" id="tgtxd_AmendmentAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem"/>
<element name="AmendmentDomain" id="tgtxd_AmendmentDomain" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="BeforeAmendmentMember" id="tgtxd_BeforeAmendmentMember" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="AfterAmendmentMember" id="tgtxd_AfterAmendmentMember" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="SettlementAgreementPayment" id="tgtxd_SettlementAgreementPayment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PromissoryNoteIssued" id="tgtxd_PromissoryNoteIssued" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="DebtInstrumentRenegotiatedPrice" id="tgtxd_DebtInstrumentRenegotiatedPrice" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PercentageOfCashProceedsFromOperationToRepayInterestOnConvertibleDebt" id="tgtxd_PercentageOfCashProceedsFromOperationToRepayInterestOnConvertibleDebt" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="OneTimeSettlementAmountForWaiverOfInterestAndPrincipalPayments" id="tgtxd_OneTimeSettlementAmountForWaiverOfInterestAndPrincipalPayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" nillable="true"/>

<element name="DebtInstrumentRepaymentTerm" id="tgtxd_DebtInstrumentRepaymentTerm" type="xbrli:durationItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="WaiverPeriodInterestAndPrincipal" id="tgtxd_WaiverPeriodInterestAndPrincipal" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" abstract="false" nillable="true"/>

<element name="LfbBiotechnologiesMember" id="tgtxd_LfbBiotechnologiesMember" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ColloborationAgreementAxis" id="tgtxd_ColloborationAgreementAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem"/>
<element name="ColloborationAgreementDomain" id="tgtxd_ColloborationAgreementDomain" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CollaborationAgreementMember" id="tgtxd_CollaborationAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" abstract="true" nillable="true"/>

<element name="StockIssuedDuringPeriodSharesLicenseOption" id="tgtxd_StockIssuedDuringPeriodSharesLicenseOption" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PossibleMilestonePayments" id="tgtxd_PossibleMilestonePayments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="BussinessAcquisitonPurchaseAgreementPeriodDescription" id="tgtxd_BussinessAcquisitonPurchaseAgreementPeriodDescription" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CommonStockValueSubscribedSubsidiarySaleOfStock" id="tgtxd_CommonStockValueSubscribedSubsidiarySaleOfStock" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CommonStockSharesSubscribedSubsidiarySaleOfStock" id="tgtxd_CommonStockSharesSubscribedSubsidiarySaleOfStock" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="SubsidiarySharesConversionSharesToBeIssued" id="tgtxd_SubsidiarySharesConversionSharesToBeIssued" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PaymentsTowardsLicense" id="tgtxd_PaymentsTowardsLicense" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PotentialRoyaltyPayment" id="tgtxd_PotentialRoyaltyPayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" nillable="true"/>

<element name="TwoThousandAndElevenEquityPipeMemberMember" id="tgtxd_TwoThousandAndElevenEquityPipeMemberMember" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="LfbGroupMember" id="tgtxd_LfbGroupMember" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ResearchDevelopmentExpesnesAxis" id="tgtxd_ResearchDevelopmentExpesnesAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem"/>
<element name="ResearchDevelopmentExpesnesDomain" id="tgtxd_ResearchDevelopmentExpesnesDomain" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ResearchDevelopmentExpesnesMember" id="tgtxd_ResearchDevelopmentExpesnesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="OpusMember" id="tgtxd_OpusMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="LegalExpensesReimbursedToAgent" id="tgtxd_LegalExpensesReimbursedToAgent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="AdvisoryFeesExpensesPrivatePlacement" id="tgtxd_AdvisoryFeesExpensesPrivatePlacement" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="EquityPipeMember" id="tgtxd_EquityPipeMember" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="AgentNonAccountableExpensesCommissionPercentageOnProceedsFromSharesIssuance" id="tgtxd_AgentNonAccountableExpensesCommissionPercentageOnProceedsFromSharesIssuance" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="DebtInstrumentRenegotiatedMaturityDate" id="tgtxd_DebtInstrumentRenegotiatedMaturityDate" type="xbrli:dateItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="MilestonePayment" id="tgtxd_MilestonePayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" nillable="true"/>
<element name="WarrantTerm" id="tgtxd_WarrantTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" abstract="false" nillable="true"/>
<element name="AgentWarrantPercentageOnIssuanceOfShares" id="tgtxd_AgentWarrantPercentageOnIssuanceOfShares" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" abstract="false" nillable="true"/>
<element name="AgentNonAccountableExpensePercentageOnGrossProceedsFromShareIssuance" id="tgtxd_AgentNonAccountableExpensePercentageOnGrossProceedsFromShareIssuance" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" abstract="false" nillable="true"/>
<element name="BusinessAcquisitionEquityInterestSharesAquired" id="tgtxd_BusinessAcquisitionEquityInterestSharesAquired" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" abstract="false" nillable="true"/>
<element name="ClassOfWarrantOrRightExcercisePriceOfSharesCallableForWarrant" id="tgtxd_ClassOfWarrantOrRightExcercisePriceOfSharesCallableForWarrant" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" abstract="false" nillable="true"/>
<element name="AdditionalDollarAmountofSharesRequiredTobePurchasedUponTheOccurrenceofCertainFinancingConditions" id="tgtxd_AdditionalDollarAmountofSharesRequiredTobePurchasedUponTheOccurrenceofCertainFinancingConditions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" nillable="true"/>

<element name="UpfrontPaymentfromLicensingAgreement" id="tgtxd_UpfrontPaymentfromLicensingAgreement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" nillable="true"/>

<element name="EmployeeServiceShareBasedCompensationNonvestedAwardTotalCompensationCostYetToBeRecognized" id="tgtxd_EmployeeServiceShareBasedCompensationNonvestedAwardTotalCompensationCostYetToBeRecognized" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" abstract="false" nillable="true"/>
<element name="SecuritiesExchangeAgreementEquityInterestSharesAquired" id="tgtxd_SecuritiesExchangeAgreementEquityInterestSharesAquired" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" abstract="false" nillable="true"/>
<element name="SecuritiesExchangeAgreementEquityInterestSharesIssued" id="tgtxd_SecuritiesExchangeAgreementEquityInterestSharesIssued" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" abstract="false" nillable="true"/>
</schema>
</XBRL>
